{"id":20798,"date":"2024-02-06T14:35:16","date_gmt":"2024-02-06T19:35:16","guid":{"rendered":"https:\/\/guleben.com\/?p=20798"},"modified":"2026-04-30T00:55:16","modified_gmt":"2026-04-30T04:55:16","slug":"obesidad-y-probioticos","status":"publish","type":"post","link":"https:\/\/guleben.com\/en\/blog\/general-public\/obesity-and-probiotics\/","title":{"rendered":"Obesity is a disease that can be corrected in time."},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"20798\" class=\"elementor elementor-20798\" data-elementor-post-type=\"post\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e341f03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e341f03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-702174b\" data-id=\"702174b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-45aba2c elementor-widget elementor-widget-text-editor\" data-id=\"45aba2c\" data-element_type=\"widget\" data-e-type=\"widget\" data-no-translation=\"\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t<style>.elementor-element-45aba2c{display:none !important}<\/style>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bac6673 elementor-widget elementor-widget-text-editor\" data-id=\"bac6673\" data-element_type=\"widget\" data-e-type=\"widget\" data-no-translation=\"\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Obesity is a disease that has become a global pandemic. At least 50% of humanity is overweight, and around 40% are obese.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">An obese patient is an inflamed person who, due to their condition, constantly produces substances that trigger a generalized inflammatory response. This, in turn, is a contributing factor to the appearance of other chronic diseases and even cancer.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The changes in eating habits, largely responsible for the obesity we see today, date back to the 1970s, when food portions were enlarged, food production increased, and \u00abexaggerated\u00bb daily energy intake became common, contributing to the rise in overweight.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">In addition, our developed society has encouraged sedentary lifestyles and high energy consumption. The result is the appearance of nutrition-related diseases such as obesity, cardiovascular diseases, type 2 diabetes, metabolic syndrome, irritable bowel syndrome, and cancer (Mart\u00ednez-Costa, 2006). There are more than half a billion people with overweight and obesity worldwide.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">On the other hand, the microbiota consists of millions of different microbes that live in our intestine and other parts of the body. They interact with us and our body, providing benefits, and we feed them through what we consume. Today, the microbiota is considered an additional organ.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">In recent decades, there has been deep research into the gut microbiota and its relationship with energy metabolism \u2014 that is, the way our body assimilates carbohydrate intake \u2014 and obesity.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">On the path to preventing and\/or managing obesity, multiple rigorous studies show that obese people have certain bacteria in their microbiota that promote obesity at elevated levels, while thin people have different microbiota bacteria. The goal is to reduce the levels of the former (Firmicutes) and increase the amount of the latter (Bacteroidetes).<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">When we look at what humans really want, we arrive at one answer: to live longer and better. If we manage to normalize our weight, we will reduce and prevent the appearance of chronic diseases such as diabetes and even cancer, and improve health, quality of life, well-being, and longevity.<\/p><h3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">What are obesity and overweight?<\/h3><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Overweight and obesity are defined as an excessive accumulation of fat that is harmful to health (<em>Manual of Probiotics<\/em>).<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Going back to the beginning of our existence, a series of \u00abthrifty genes\u00bb were necessary for the survival of our gatherer and hunter ancestors. This factor still exists today and, together with other environmental conditions, favors obesity.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Obesity is measured through the <strong>body mass index (BMI)<\/strong>, which is the result of the ratio between weight and the square of height (kg\/m\u00b2). A BMI greater than 30 means obesity, and a BMI greater than 25 is overweight.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Two concepts to keep in mind:<\/p><ul class=\"[li_&amp;]:mb-0 [li_&amp;]:mt-1 [li_&amp;]:gap-1 [&amp;:not(:last-child)_ul]:pb-1 [&amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"><li class=\"whitespace-normal break-words pl-2\">The \u00abthrifty gene\u00bb is no longer necessary today; however, individuals more susceptible to this gene, along with insulin and leptin resistance (which translates to the difficulty of these hormones in acting on cells), have a higher likelihood of developing extreme obesity (Serrano R\u00edos et al., 2006).<\/li><li class=\"whitespace-normal break-words pl-2\">Obesity and overweight are risk factors that increase the likelihood of suffering from chronic diseases such as diabetes, cardiovascular diseases, and cancer (Covarrubias, 2020). Obesity also substantially increases the risk of depression, anxiety, and dementia (Anderson et al., 2017). In other words, obesity affects both our body and our mind.<\/li><\/ul><h3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Obesity statistics<\/h3><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">According to the WHO, in 2016, more than 1.9 billion adults over 18 were overweight (39%); of these, 650 million were obese (13%). By 2016, 41 million children under five were overweight or obese. More than 340 million children and adolescents (5 to 19 years old) were overweight or obese.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">In Colombia, children between 5 and 12 years old are overweight at 24.4%, adolescents between 13 and 17 at 17.9%, and adults reach 56.5%, with a higher rate in women at 59.6%; in this group, the rate of overweight is 37.8% and obesity 18.7%.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">In addition, two-thirds of children remain glued to screens, which is a contributing factor to overweight and obesity. The same goes for sedentary lifestyles, which affect an average of 15% of children and increase to 25% in adults.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Another factor acting as an obesogenic agent since the pandemic is the emotional crisis being experienced by adolescents and adults. Depression itself is a risk factor for obesity due to the urge to keep eating, and the use of antidepressants or even antipsychotics is associated with weight gain.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Obesity affects the brain and includes problems with learning and memory (Anderson, Cryan, and Dinan, 2020). These neuronal changes affect adulthood with the appearance of depression and dementia.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Obesity is an accelerator of aging, and likewise, there is the possibility of an earlier appearance of neurological diseases typical of old age.<\/p><h3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Microbiota and obesity<\/h3><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Research on the gut microbiota&#8217;s relationship with metabolic functions and obesity has been advancing for years. Both obesity and the gut microbiota depend on genetic and environmental factors.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The microbiota is essential to achieve metabolic, homeostatic, and physiological balance in the body&#8217;s organ systems.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The microbiota can vary due to external factors including diet, antibiotics, medications, and even the type of birth. C-section delivery can be a factor that favors obesity.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The Western diet is rich in sugars and fats. Many of these fats are not digested in the digestive tract and are processed by the human microbiota. Through this pathway, energy intake increases, leading to fat deposits and favoring overweight and obesity.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Another factor is the genes of the microbes themselves housed in communities; these genes outnumber human genes by 100 times. Many of these genes act on several foods we eat that aren&#8217;t processed by our digestive system. The result? An increase in the amount of energy that can be extracted from these foods (Cani and Delzenne, 2007). You guessed it: fat deposits.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">There are three mechanisms that explain the increase in fat associated with the gut microbiota:<\/p><ol class=\"[li_&amp;]:mb-0 [li_&amp;]:mt-1 [li_&amp;]:gap-1 [&amp;:not(:last-child)_ul]:pb-1 [&amp;:not(:last-child)_ol]:pb-1 list-decimal flex flex-col gap-1 pl-8 mb-3\"><li class=\"whitespace-normal break-words pl-2\">An increase in the intestinal absorption of glucose.<\/li><li class=\"whitespace-normal break-words pl-2\">The generation of short-chain fatty acids through microbial fermentation of the diet.<\/li><li class=\"whitespace-normal break-words pl-2\">A stimulus to the generation of lipids or fats secondary to increases in sugar and insulin levels in the blood (B\u00e4ckhed et al., 2004).<\/li><\/ol><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The microbiota must live in a constant balance. Certain microbe families have been linked to obesity due to the presence in the intestine of specific germs that also secrete substances that contribute to inflammation in the body.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Cleaning, balancing, and improving the intestinal highway and, in turn, the gut microbiota is a trigger for achieving a healthy weight.<\/p><h3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">How do some probiotics help control and reverse obesity?<\/h3><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">If the microbiota influences the development of obesity, it makes sense to think that factors that modify it \u2014 such as prebiotics, probiotics, and the new postbiotics \u2014 can have a therapeutic effect on this disease.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">An obese individual, being inflamed, has <strong>intestinal permeability<\/strong>. This means that many substances that should remain inside the intestine, often pro-inflammatory, pass into the bloodstream. By improving certain families of bacteria, we improve the intestine&#8217;s own activity, the first and most important being intestinal permeability.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Intestinal permeability is a condition of the intestine where substances that shouldn&#8217;t pass into the blood manage to do so, and from there reach the rest of the body through circulation. This causes allergies, chronic inflammation, and other harmful situations for health.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Some probiotics and postbiotics used in research and development increase the amount of certain very beneficial bacteria in mucus production, such as <em>Akkermansia muciniphila<\/em> and <em>Faecalibacterium prausnitzii<\/em>.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The probiotics and postbiotics used also have an effect on appetite and satiety, improving the pathways associated with an amino acid called <strong>tryptophan<\/strong>, which helps with the feeling of fullness, reducing hunger and the urge to eat.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Several studies with specialized strains of postbiotics aimed at reducing waist circumference work by burning and breaking down the fat that exists under the skin and between the abdominal organs. They help reduce weight and improve blood sugar, fat, and triglyceride levels.<\/p><h3 class=\"text-text-100 mt-3 -mb-1 text-[1.125rem] font-bold\">Conclusions<\/h3><ul class=\"[li_&amp;]:mb-0 [li_&amp;]:mt-1 [li_&amp;]:gap-1 [&amp;:not(:last-child)_ul]:pb-1 [&amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"><li class=\"whitespace-normal break-words pl-2\">We have specialized postbiotics that help burn intestinal fat in a healthy and natural way.<\/li><li class=\"whitespace-normal break-words pl-2\">By improving the gut microbiota, we improve digestive function, which includes the digestion and absorption of food; this way, we get better nutrition.<\/li><li class=\"whitespace-normal break-words pl-2\">This also reduces inflammation in the body by stopping intestinal permeability, preventing the passage of harmful substances into the blood.<\/li><li class=\"whitespace-normal break-words pl-2\">We reduce the amount of fat and triglycerides by modifying the microbe families in the intestine.<\/li><li class=\"whitespace-normal break-words pl-2\">We improve how cells use insulin, benefiting the health of people with type 2 diabetes.<\/li><li class=\"whitespace-normal break-words pl-2\">We will live longer and better because we prevent the appearance of chronic non-communicable and often degenerative diseases.<\/li><li class=\"whitespace-normal break-words pl-2\">If we improve weight, we improve memory and attention.<\/li><li class=\"whitespace-normal break-words pl-2\">We reduce anxiety and the risk of depression, as well as the appearance of diseases such as Alzheimer&#8217;s.<\/li><li class=\"whitespace-normal break-words pl-2\">We help prevent cancer.<\/li><\/ul><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">All of the above are reasons to care for, promote, improve, balance, change, and properly feed our gut microbiota.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>La obesidad es una enfermedad que se convirti\u00f3 en una pandemia mundial. Al menos un 50% de la humanidad tiene sobrepeso y cerca del 40% son obesos. El paciente obeso es una persona inflamada, quien por su condici\u00f3n produce constantemente sustancias que generan una respuesta de inflamaci\u00f3n generalizada, lo cual a su vez es un [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":23710,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5],"tags":[],"class_list":["post-20798","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-publico-general"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>La Obesidad una enfermedad que puede corregirse a tiempo &#8211; Guleben<\/title>\n<meta name=\"description\" content=\"La obesidad es una enfermedad que se convirti\u00f3 en una pandemia mundial. 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